Examples of Our Work with CNS Therapies
Integrated Modeling and Simulation Approach to Support Competitive Assessment and Dose Selection in Alzheimer's Disease
View archived webinar/download presentation
Decision-Focused Applications of Modeling and Simulation in CNS Drug Development:
Four Case Studies
- Combining pre-clinical and clinical evidence to support an early Phase II go/no-go decision (generalized anxiety disorder)
- Integrating dose-response modeling and decision analysis for late Phase II dose optimization (major depressive disorder)
- Applying modeling and clinical trial simulation for proof-of-concept trial design and analysis (neurodegenerative disease)
- Modeling, trial simulation and decision analysis in an adaptive trial design for proof of concept and dose finding (chronic psychiatric disorder)
Modeling and Simulation Applications in CNS Drug Development 
®
Evaluating Safety and Efficacy Tradeoffs to Support Go/No-Go Decision for an Anti-Depressant in Early Development
Decision Analysis Clarifies a Difficult Go/No-Go Decision: The NK1 Antagonist Case
Label Expansion Case Study: Cephalon Modeling and Simulation Experience Developing Provigil™
The Collaborative and Strategic Benefits of Exploring Drug Models in Clinical Development
Play Web-Based Case Study (sign-in required)
Case Studies in Neuroscience Drug Development and Commercialization
Accelerating Profitable CNS Compound Development: Pre-clinical to Phase III, Bayesian Modeling, Adaptive Trial Design, Decision Analysis